Talin: a protein designed for mechanotransduction
نویسندگان
چکیده
منابع مشابه
Force-induced activation of talin and its possible role in focal adhesion mechanotransduction.
It is now well established that cells can sense mechanical force, but the mechanisms by which force is transduced into a biochemical signal remain poorly understood. One example is the recruitment of vinculin to reinforce initial contacts between a cell and the extracellular matrix (ECM) due to tensile force. Talin, an essential linking protein in an initial contact, contains at least one vincu...
متن کاملMechanotransduction In Vivo by Repeated Talin Stretch-Relaxation Events Depends upon Vinculin
Mechanotransduction is a critical function for cells, in terms of cell viability, shaping of tissues, and cellular behavior. In vitro, cellular level forces can stretch adhesion proteins that link extracellular matrix to the actin cytoskeleton exposing hidden binding sites. However, there is no evidence that in vivo forces produce significant in vivo stretching to cause domain unfolding. We now...
متن کاملTalin for presynaptic endocytosis
plicing factors, usually associated with RNA polymerase II transcripts, have a temporary home near sites of RNA polymerase I transcription, as shown on page 51 by Bubulya et al. During interphase, premRNA splicing factors such as the serine arginine–rich (SR) proteins reside in nuclear speckles, along with other pre-mRNA processing proteins. The speckles disassemble during mitosis, and then ref...
متن کاملDesigned Spiroketal Protein Modulation
Spiroketals are structural motifs found in many biologically active natural products, which has stimulated considerable efforts toward their synthesis and interest in their use as drug lead compounds. Despite this, the use of spiroketals, and especially bisbenzanulated spiroketals, in a structure-based drug discovery setting has not been convincingly demonstrated. Herein, we report the rational...
متن کاملA role for talin in presynaptic function
Talin, an adaptor between integrin and the actin cytoskeleton at sites of cell adhesion, was recently found to be present at neuronal synapses, where its function remains unknown. Talin interacts with phosphatidylinositol-(4)-phosphate 5-kinase type Igamma, the major phosphatidylinositol-(4,5)-bisphosphate [PI(4,5)P(2)]-synthesizing enzyme in brain. To gain insight into the synaptic role of tal...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Emerging Topics in Life Sciences
سال: 2018
ISSN: 2397-8554,2397-8562
DOI: 10.1042/etls20180179